Who would I want to direct Isolation? Well, after this year's The Happening, I'm not sure I'd want M. Night Shyamalan to direct anything of mine. I hate criticizing any artist, but that was not up to his standards. But going back to The Sixth Sense and Signs, Shyamalan knows how to scare while also telling a delicate story. Here's a story he wouldn't have to write--he could just direct it.
For the score, I would pick the go-to guy that Shyamalan uses: James Newton Howard. I listened to the score of The Village a lot while writing this.